Polymerase bypass of N7-guanine monoadducts of cisplatin, diepoxybutane, and epichlorohydrin
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چکیده
منابع مشابه
Fluorescence quantification of aflatoxin N7-guanine adducts.
Increasingly sensitive assays are needed to understand and evaluate the effects of chemical exposures on individuals and populations. Several assays have been developed to measure the environmental dietary carcinogen, aflatoxin, and its metabolites in biological specimens. One, the 8,9-dihydro-8-(N7-guanyl)-9-hydroxy-aflatoxin B1 nucleic acid adduct, has been shown to be both highly correlated ...
متن کاملCytotoxicity of Diepoxybutane and Epichlorohydrin in Relation to Stages of the Cell Cycle
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متن کاملDNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards.
Nitrogen mustards alkylate DNA primarily at the N7 position of guanine. Using an approach analogous to that of the Maxam-Gilbert procedure for DNA sequence analysis, we have examined the relative frequencies of alkylation for a number of nitrogen mustards at different guanine-N7 sites on a DNA fragment of known sequence. Most nitrogen mustards were found to have similar patterns of alkylation, ...
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ژورنال
عنوان ژورنال: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
سال: 2018
ISSN: 0027-5107
DOI: 10.1016/j.mrfmmm.2018.03.002